Since I don't have specific information about this particular title, the guide might need to be a bit generic but tailored to the structure implied by the title. Maybe start with general sections that can be applied, such as understanding the story context, character development, themes, and so on.
Alternatively, if it's a visual novel, the guide would involve making choices that affect the story, so maybe focusing on dialogue options that lead to a good ending. If it's a manga, then maybe episode/Chapter summaries. Anna Exciting Affection -Ch.2 Ep.18-
Next, how to structure the guide. They probably want a step-by-step guide for progressing through the content. So sections like Story Overview, Key Characters, Gameplay Tips (if it's a game), Dialogue Choices, Ending Routes, etc. Since I don't have specific information about this